We present in this paper the application of multiagent system (MAS) for modelling and simulation of the dynamic structure and behaviour of the supply chain in SMEs mechatronic context in Savoie. First, a short literature overview describes the context and the contribution of multiagent modelling for SMEs integration. In the rest of the paper, the supply chain concepts and their agentification are presented. On the basis of this correspondence, we propose a synchronization protocol for the operational system (production flow and resources).