To tackle the complexity and heterogeneity of the networks that integrate Mechatronic SMEs, this paper describes a modelling and simulation solution based on multiagent system and ArchMDE (Architecture Model Drive Engineering) methodology for supply chain agentification. This research work outlines two main results: conceptualisation and modelling. The first one deals with the identification and concepts definition of the different entities moving and acting into the multiagent and supply chain systems. The second one discusses the agent approach providing a framework naturally oriented to model supply chain concepts and their dynamic behavior.