Concurrent Clade I and Clade II Monkeypox Virus Circulation, Cameroon, 1979-2022 - Centre Pasteur du Cameroun
Article Dans Une Revue Emerging Infectious Diseases Année : 2024

Concurrent Clade I and Clade II Monkeypox Virus Circulation, Cameroon, 1979-2022

Résumé

During 1979–2022, Cameroon recorded 32 laboratory-confirmed mpox cases among 137 suspected mpox cases identified by the national surveillance network. The highest positivity rate occurred in 2022, indicating potential mpox re-emergence in Cameroon. Both clade I (n = 12) and clade II (n = 18) monkeypox virus (MPXV) were reported, a unique feature of mpox in Cameroon. The overall case-fatality ratio of 2.2% was associated with clade II. We found mpox occurred only in the forested southern part of the country, and MPXV phylogeographic structure revealed a clear geographic separation among concurrent circulating clades. Clade I originated from eastern regions close to neighboring mpox-endemic countries in Central Africa; clade II was prevalent in western regions close to West Africa. Our findings suggest that MPXV re-emerged after a 30-year lapse and might arise from different viral reservoirs unique to ecosystems in eastern and western rainforests of Cameroon.
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pasteur-04669695 , version 1 (09-08-2024)

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Dd Djuicy, Sa Sadeuh-Mba, Cn Bilounga, Mg Yonga, Jb Tchatchueng-Mbougua, et al.. Concurrent Clade I and Clade II Monkeypox Virus Circulation, Cameroon, 1979-2022. Emerging Infectious Diseases, 2024, 30 (3), pp.432-443. ⟨10.3201/eid3003.230861⟩. ⟨pasteur-04669695⟩
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